LL-37.png
LL-37.png

LL-37

$110.00

LL-37 is a cationic antimicrobial peptide with wide-ranging activity against microbes. In addition to membrane disruption, it plays a role in immune modulation by interacting with PRRs, helping to balance inflammation, support tissue repair, and neutralize LPS. These properties have positioned LL-37 as an important focus in research related to inflammation and antimicrobial resistance.

LL-37 is a cationic antimicrobial peptide with wide-ranging activity against microbes. In addition to membrane disruption, it plays a role in immune modulation by interacting with PRRs, helping to balance inflammation, support tissue repair, and neutralize LPS. These properties have positioned LL-37 as an important focus in research related to inflammation and antimicrobial resistance.

LL-37 is a cationic, amphipathic antimicrobial peptide of the cathelicidin family, consisting of a 37-amino-acid sequence derived from the hCAP18 precursor. It demonstrates broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria, fungi, and viruses through disruption of microbial membrane integrity and induction of intracellular disturbances. LL-37 participates in immune modulation by interacting with pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and formyl peptide receptor-like 1 (FPRL1), leading to regulated inflammatory cytokine signaling and chemotactic responses in non-human test subjects. In addition, it supports angiogenesis and epithelial cell migration, contributing to wound repair mechanisms. The peptide has also been shown to influence immune responses in animal test subjects by binding and neutralizing lipopolysaccharides (LPS), thereby reducing endotoxin-mediated inflammatory pathways.